Top 13 bacteroides fragilis treatment in 2022

Below are the best information and knowledge on the subject bacteroides fragilis treatment compiled and compiled by our own team alltopus:

1. Bacteroides Fragilis

Author: www.ncbi.nlm.nih.gov

Date Submitted: 03/07/2020 06:49 PM

Average star voting: 3 ⭐ ( 49808 reviews)

Summary: Anaerobes are bacteria that do not require oxygen to live. Anaerobes usually fit into two groups based on their gram stain into gram-positive and gram-negative and into cocci and bacilli based on their morphology. Of these, notable pathogenic gram-negative bacillus-shaped strains are Prevotella, Fusobacterium, Bacteroides, and Porphyromonas. Bacteroides species are important clinical pathogens and are present in most anaerobic infections, with an associated mortality of approximately 19%.[1] Bacteroides fragilis is an obligate anaerobic gram-negative bacillus. The human colon has the greatest population of bacteria in the body (over ten organisms per gram of wet weight), and the largest part of these organisms are anaerobes; of these, approximately 25% are species of Bacteroides.[2] Bacteroides fragilis is part of the normal microbiota of the human colon. Disruption of the mucosal surface either by inflammation, trauma, or surgery and spread of Bacteroides fragilis to the bloodstream or surrounding tissues results in clinically significant infection.

Match with the search results: have low levels of susceptibility for Bacteroides fragilis, whereas Piperacillin/tazobactam, meropenem, and metronidazole have high susceptibility rates. [23] Metronidazole is the antibiotic of choice for the management of infections caused by anaerobes….. read more

Bacteroides Fragilis

2. Bacteroides Infection Treatment & Management: Medical Care, Surgical Care

Author: emedicine.medscape.com

Date Submitted: 04/04/2021 02:18 PM

Average star voting: 3 ⭐ ( 37966 reviews)

Summary: This article describes infections caused by the Bacteroides fragilis group and other anaerobic gram-negative bacilli (AGNB) that were previously included in the Bacteroides genus but are now included in the Prevotella and Porphyromonas genera. In addition, many new genera and several new species have been created to accommodate pathogens, suc…

Match with the search results: Cefoxitin is the most effective cephalosporin against the B fragilis group, although 5-15% may be resistant. Cefoxitin is inactive against most ……. read more

Bacteroides Infection Treatment & Management: Medical Care, Surgical Care

3. Bacteroides species | Johns Hopkins ABX Guide

Author: www.hopkinsguides.com

Date Submitted: 03/05/2019 12:55 AM

Average star voting: 5 ⭐ ( 38108 reviews)

Summary: Bacteroides species answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.

Match with the search results: B. fragilis group almost always susceptible to metronidazole, carbapenems, beta-lactam/beta-lactamase inhibitors….. read more

Bacteroides species | Johns Hopkins ABX Guide

4. Bacteroides Fragilis

Author: www.hopkinsguides.com

Date Submitted: 02/11/2019 06:51 PM

Average star voting: 5 ⭐ ( 52980 reviews)

Summary: A publicly available article also appearing in PubMed about Bacteroides Fragilis

Match with the search results: Due to increasing rates of resistance, do not use the following drugs for severe infections where B. fragilis is suspected: most resistance due ……. read more

Bacteroides Fragilis

5. Metronidazole treatment of Bacteroides fragilis infections

Author: www.statpearls.com

Date Submitted: 09/13/2019 12:43 AM

Average star voting: 3 ⭐ ( 90048 reviews)

Summary:

Match with the search results: The management of Bacteroides fragilis infection is usually by source control either by incision and drainage of the pus or aspiration along ……. read more

Metronidazole treatment of Bacteroides fragilis infections

6. Anaerobic Sepsis Due to Multidrug-Resistant Bacteroides fragilis: Microbiological Cure and Clinical Response with Linezolid Therapy

Author: www.sciencedirect.com

Date Submitted: 09/29/2021 05:49 PM

Average star voting: 5 ⭐ ( 98038 reviews)

Summary: Abstract. We describe the first reported case of anaerobic sepsis due to Bacteroides fragilis with simultaneous resistance to metronidazole, β-lactams, β-lactam

Match with the search results: Seven patients with Bacteroides fragilis infections were treated with intravenous and/or oral metronidazole. Infections treated included endocarditis, ……. read more

Anaerobic Sepsis Due to Multidrug-Resistant Bacteroides fragilis: Microbiological Cure and Clinical Response with Linezolid Therapy

7. Antimicrobial Resistance and Clinical Outcome of Bacteroides Bacteremia: Findings of a Multicenter Prospective Observational Trial

Author: academic.oup.com

Date Submitted: 06/26/2020 06:04 AM

Average star voting: 5 ⭐ ( 91832 reviews)

Summary: Abstract. There is debate regarding the correlation between in vitro susceptibility testing and clinical response to therapy for bacteroides bacteremia. We cond

Match with the search results: Treatment was complicated by Candida guilliermondii fungemia, which required liposomal amphotericin B therapy. The isolation of B. fragilis from intra-abdominal ……. read more

Antimicrobial Resistance and Clinical Outcome of Bacteroides Bacteremia: Findings of a Multicenter Prospective Observational Trial

8. Multidrug-Resistant Bacteroides fragilis — Seattle, Washington, 2013

Author: academic.oup.com

Date Submitted: 11/07/2020 10:08 PM

Average star voting: 4 ⭐ ( 92467 reviews)

Summary:

Match with the search results: Bacteroides fragilis ATCC 25285 and Bacteroides thetaiotaomicron ATCC 29741 were used … Treatment was considered to be a clinical failure if (1) signs and ……. read more

Multidrug-Resistant Bacteroides fragilis — Seattle, Washington, 2013

9. Antibiotic resistance pattern of Bacteroides fragilis isolated from clinical and colorectal specimens – Annals of Clinical Microbiology and Antimicrobials

Author: www.cdc.gov

Date Submitted: 07/11/2021 04:19 PM

Average star voting: 3 ⭐ ( 20745 reviews)

Summary: Bacteroides fragilis is a part of the normal gastrointestinal flora, but it is also the most common anaerobic bacteria causing the infection. It is highly resistant to antibiotics and contains abundant antibiotic resistance mechanisms. The antibiotic resistance pattern of 78 isolates of B. fragilis (22 strains from clinical samples and 56 strains from the colorectal tissue) was investigated using agar dilution method. The gene encoding Bacteroides fargilis toxin bft, and antibiotic resistance genes were targeted by PCR assay. The highest rate of resistance was observed for penicillin G (100%) followed by tetracycline (74.4%), clindamycin (41%) and cefoxitin (38.5%). Only a single isolate showed resistance to imipenem which contained cfiA and IS1186 genes. All isolates were susceptible to metronidazole. Accordingly, tetQ (87.2%), cepA (73.1%) and ermF (64.1%) were the most abundant antibiotic-resistant genes identified in this study. MIC values for penicillin, cefoxitin and clindamycin were significantly different among isolates with the cepA, cfxA and ermF in compare with those lacking such genes. In addition, 22.7 and 17.8% of clinical and GIT isolates had the bft gene, respectively. The finding of this study shows that metronidazole is highly in vitro active agent against all of B. fragilis isolates and remain the first-line antimicrobial for empirical therapy.

Match with the search results: Based on a published report of successful use of linezolid for the treatment of an intra-abdominal infection with MDR B. fragilis (4), ……. read more

Antibiotic resistance pattern of Bacteroides fragilis isolated from clinical and colorectal specimens - Annals of Clinical Microbiology and Antimicrobials

10. Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe

Author: ann-clinmicrob.biomedcentral.com

Date Submitted: 11/11/2020 07:54 PM

Average star voting: 3 ⭐ ( 54927 reviews)

Summary:

Match with the search results: In our study, metronidazole was only the most in vitro active agent against all of B. fragilis isolates and should be considered as a first-line ……. read more

Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe

11. Bacteroides fragilis endocarditis, bacteremia and other infections treated with oral or intravenous metronidazole

Author: www.clinicalmicrobiologyandinfection.com

Date Submitted: 04/24/2019 05:45 PM

Average star voting: 5 ⭐ ( 51316 reviews)

Summary:

Match with the search results: have low levels of susceptibility for Bacteroides fragilis, whereas Piperacillin/tazobactam, meropenem, and metronidazole have high susceptibility rates. [23] Metronidazole is the antibiotic of choice for the management of infections caused by anaerobes….. read more

Bacteroides fragilis endocarditis, bacteremia and other infections treated with oral or intravenous metronidazole

12. Bacteroides fragilis Protects Against Antibiotic-Associated Diarrhea in Rats by Modulating Intestinal Defenses

Author: www.amjmed.com

Date Submitted: 02/16/2020 03:19 AM

Average star voting: 4 ⭐ ( 64864 reviews)

Summary: Antibiotic-associated diarrhea (AAD) is iatrogenic diarrhea characterized by disruption of the gut microbiota. Probiotics are routinely used to treat AAD in clinical practice; however, the effectiveness and mechanisms by which probiotics alleviate symptoms remain poorly understood. We previously isolated a non-toxic Bacteroides fragilis (B. fragilis) strain ZY-312, which has been verified to be beneficial in certain infection disorders. However, the precise role of this commensal bacterium in AAD is unknown. In this study, we successfully established an AAD rat model by exposing rats to appropriate antibiotics. These rats developed diarrhea symptoms and showed alterations in their intestinal microbiota, including overgrowth of some pathogenic bacteria. In addition, gastrointestinal barrier defects, indicated by compromised aquaporin expression, aberrant tight junction proteins, and decreased abundance of mucus-filled goblet cells, were also detected in ADD rats compared with control animals. Of note, oral treatment with Bacteroides B. fragilis strain ZY-312 ameliorated AAD-related diarrhea symptoms by increasing the abundance of specific commensal microbiota. Interestingly, we demonstrated that these changes were coincident with the restoration of intestinal barrier function and enterocyte regeneration in AAD rats. In summary, we identified a potential probiotic therapeutic strategy for AAD, and identified the vital roles of Bacteroides B. fragilis strain ZY-312 in modulating the colonic bacterial community and participating in microbiota-mediated epithelial cell proliferation and differentiation.

Match with the search results: Cefoxitin is the most effective cephalosporin against the B fragilis group, although 5-15% may be resistant. Cefoxitin is inactive against most ……. read more

Bacteroides fragilis Protects Against Antibiotic-Associated Diarrhea in Rats by Modulating Intestinal Defenses

13. Bacteroides fragilis

Author: www.frontiersin.org

Date Submitted: 09/01/2019 10:37 PM

Average star voting: 4 ⭐ ( 62575 reviews)

Summary: Bacteroides fragilis – GlobalRPH

Match with the search results: B. fragilis group almost always susceptible to metronidazole, carbapenems, beta-lactam/beta-lactamase inhibitors….. read more

Bacteroides fragilis

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