Top 16 biofilm treatment in 2022

Below are the best information and knowledge on the subject biofilm treatment compiled and compiled by our own team alltopus:

1. Strategies for combating bacterial biofilm infections | International Journal of Oral Science

Author: www.nature.com

Date Submitted: 07/26/2019 04:24 PM

Average star voting: 4 ⭐ ( 22202 reviews)

Summary: Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living environment, especially in the hostile environment. Under the protection of biofilm, microbial cells in biofilm become tolerant and resistant to antibiotics and the immune responses, which increases the difficulties for the clinical treatment of biofilm infections. Clinical and laboratory investigations demonstrated a perspicuous correlation between biofilm infection and medical foreign bodies or indwelling devices. Clinical observations and experimental studies indicated clearly that antibiotic treatment alone is in most cases insufficient to eradicate biofilm infections. Therefore, to effectively treat biofilm infections with currently available antibiotics and evaluate the outcomes become important and urgent for clinicians. The review summarizes the latest progress in treatment of clinical biofilm infections and scientific investigations, discusses the diagnosis and treatment of different biofilm infections and introduces the promising laboratory progress, which may contribute to prevention or cure of biofilm infections. We conclude that, an efficient treatment of biofilm infections needs a well-established multidisciplinary collaboration, which includes removal of the infected foreign bodies, selection of biofilm-active, sensitive and well-penetrating antibiotics, systemic or topical antibiotic administration in high dosage and combinations, and administration of anti-quorum sensing or biofilm dispersal agents. Antibiotics alone are often ineffective in the treatment of bacterial biofilm infections and new strategies are needed. Once bacteria shift from their free-swimming state to the structured community of a biofilm, they become much harder to kill with conventional antibiotic regimens. A review by Zhi-Jun Song and colleagues at Denmark’s University Hospital of Copenhagen explores the challenges of diagnosing and eliminating biofilms that form on the surface of implanted medical devices. At present, the best solution is early detection followed by aggressive treatment with multiple antibiotics and removal of the device in question. However, recent research suggests other possible solutions, including drugs that interfere with communication between bacteria or disrupt their ability to anchor to surfaces, and viruses that specifically infect and kill biofilm-forming microbes.

Match with the search results: removal of infected indwelling devices, selection of well penetrating and sensitive antibiotics, early administration of high dosage antibiotics in combination and supplemented with anti-QS treatment and/or biofilm dispersal agents…. read more

Strategies for combating bacterial biofilm infections | International Journal of Oral Science

2. Bacterial Biofilm Eradication Agents: A Current Review

Author: www.frontiersin.org

Date Submitted: 08/29/2021 11:46 PM

Average star voting: 4 ⭐ ( 41842 reviews)

Summary: Most free-living bacteria can attach to surfaces and aggregate to grow into multicellular communities encased in extracellular polymeric substances called biofilms. Biofilms are recalcitrant to antibiotic therapy and a major cause of persistent and recurrent infections by clinically important pathogens worldwide (e.g., Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus). Currently, most biofilm remediation strategies involve the development of biofilm-inhibition agents, aimed at preventing the early stages of biofilm formation, or biofilm-dispersal agents, aimed at disrupting the biofilm cell community. While both strategies offer some clinical promise, neither represents a direct treatment and eradication strategy for established biofilms. Consequently, the discovery and development of biofilm eradication agents as comprehensive, stand-alone biofilm treatment options has become a fundamental area of research. Here we review our current understanding of biofilm antibiotic tolerance mechanisms and provide an overview of biofilm remediation strategies, focusing primarily on the most promising biofilm eradication agents and approaches. Many of these offer exciting prospects for the future of biofilm therapeutics for the large number of infections that are currently refractory to conventional antibiotics.

Match with the search results: Consequently, these treatments are often ineffective against pathogenic biofilms (Costerton et al., 1987; ……. read more

Bacterial Biofilm Eradication Agents: A Current Review

3. Dangerous Slimes: How Bacterial Biofilms Make You Sick and How to Combat Them

Author: www.frontiersin.org

Date Submitted: 01/14/2021 07:02 AM

Average star voting: 4 ⭐ ( 61655 reviews)

Summary: Yes, we can house dangerous slimes called biofilms in our bodies. They can cause severe infections anywhere in our bodies. They contain bacteria hidden and hibernating in a protective matrix. This makes them really difficult to treat. They like to stick on implanted material like prostheses or catheter. They can also persist on your teeth, in your ears, even sometimes in your lungs. Luckily, researchers are very aware of this problem. They are experimenting with diverse solutions to try to destroy these biofilms. Are you curious about their brilliant ideas? Then follow us to learn more about how biofilms make you sick and how we try to combat them.

Match with the search results: Eventually, they become resistant to the treatment and in the end, antibiotics will no longer work to fight off the infection at all. Figure 1 – ……. read more

Dangerous Slimes: How Bacterial Biofilms Make You Sick and How to Combat Them

4. Novel approaches to the treatment of bacterial biofilm infections

Author: www.ncbi.nlm.nih.gov

Date Submitted: 05/30/2020 12:54 AM

Average star voting: 4 ⭐ ( 86551 reviews)

Summary:

Match with the search results: One novel approach to treat biofilms is the use of photo inactivation where light is used to either directly damage bacteria by exciting intracellular ……. read more

Novel approaches to the treatment of bacterial biofilm infections

5. Biofilm: What It Is and How to Treat It – Kresser Institute

Author: kresserinstitute.com

Date Submitted: 01/29/2019 03:45 PM

Average star voting: 3 ⭐ ( 10968 reviews)

Summary: Biofilm: What It Is and How to Treat It . Find more Digestive Disorders, Functional Medicine articles on Kresser Institute

Match with the search results: Antibiotic after antibiotic for IBD. Corticosteroids for CRS. If a biofilm is at work, these standard “treatments” aren’t curing anything….. read more

Biofilm: What It Is and How to Treat It - Kresser Institute

6. Current developments in biofilm treatments: Wound and implant infections

Author: www.sciencedirect.com

Date Submitted: 02/07/2021 05:23 PM

Average star voting: 4 ⭐ ( 45946 reviews)

Summary:

Match with the search results: Ultrasound debridement can treat biofilm-infected wounds, and has been reported to increase the effectiveness of antibiotics and promote wound healing [52], [53] ……. read more

Current developments in biofilm treatments: Wound and implant infections

7. Antibiotics versus biofilm: an emerging battleground in microbial communities – Antimicrobial Resistance & Infection Control

Author: onlinelibrary.wiley.com

Date Submitted: 06/25/2019 01:50 AM

Average star voting: 4 ⭐ ( 87482 reviews)

Summary: Biofilm is a complex structure of microbiome having different bacterial colonies or single type of cells in a group; adhere to the surface. These cells are embedded in extracellular polymeric substances, a matrix which is generally composed of eDNA, proteins and polysaccharides, showed high resistance to antibiotics. It is one of the major causes of infection persistence especially in nosocomial settings through indwelling devices. Quorum sensing plays an important role in regulating the biofilm formation. There are many approaches being used to control infections by suppressing its formation but CRISPR-CAS (gene editing technique) and photo dynamic therapy (PDT) are proposed to be used as therapeutic approaches to subside bacterial biofim infections, especially caused by deadly drug resistant bad bugs.

Match with the search results: While for device-associated biofilms removal of the implant (when possible) is the best therapeutic alternative, for tissue or sputum-associated ……. read more

Antibiotics versus biofilm: an emerging battleground in microbial communities - Antimicrobial Resistance & Infection Control

8. Antibiofilm peptides: overcoming biofilm-related treatment failure – RSC Advances (RSC Publishing) DOI:10.1039/D0RA09739J

Author: aricjournal.biomedcentral.com

Date Submitted: 11/07/2019 07:22 PM

Average star voting: 3 ⭐ ( 41764 reviews)

Summary:

Match with the search results: Successful treatment of biofilm-associated infections is troubled due to high antibiotic resistance in these bacterial communities….. read more

Antibiofilm peptides: overcoming biofilm-related treatment failure - RSC Advances (RSC Publishing) DOI:10.1039/D0RA09739J

9. Antibacterial Liquid Metals: Biofilm Treatment via Magnetic Activation

Author: pubs.rsc.org

Date Submitted: 01/19/2021 04:07 AM

Average star voting: 3 ⭐ ( 44096 reviews)

Summary:

Match with the search results: Biofilms resist clearance by multiple antibiotics and have a major role in chronic infections, causing more than 65% of all infections. No ……. read more

Antibacterial Liquid Metals: Biofilm Treatment via Magnetic Activation

10. Diagnosis and treatment of biofilm infections in children : Current Opinion in Infectious Diseases

Author: pubs.acs.org

Date Submitted: 06/21/2019 06:38 PM

Average star voting: 3 ⭐ ( 56250 reviews)

Summary:

Match with the search results: Antibiotic resistance has made the treatment of biofilm-related infections challenging. As such, the quest for next-generation antimicrobial ……. read more

Diagnosis and treatment of biofilm infections in children : Current Opinion in Infectious Diseases

11. Biofilm Treatment Protocol: Natural Biofilm Disruptors That Work

Author: journals.lww.com

Date Submitted: 11/17/2019 04:09 PM

Average star voting: 5 ⭐ ( 53949 reviews)

Summary: Biofilms are often overlooked when working on gut healing. But now we know
they are a critical component of successful treatment for many of the root
causes of IBS. So in this post, I’m going to provide an overview of my
natural biofilm treatment protocol as well as explain why biofilm
disruptors are such an important part of eradicating parasites, bacteria,
SIBO, yeast and other pathogenic infections.

Match with the search results: removal of infected indwelling devices, selection of well penetrating and sensitive antibiotics, early administration of high dosage antibiotics in combination and supplemented with anti-QS treatment and/or biofilm dispersal agents…. read more

Biofilm Treatment Protocol: Natural Biofilm Disruptors That Work

12. Biofilm in dermatology – Journal of Skin and Sexually Transmitted Diseases

Author: bellalindemann.com

Date Submitted: 01/18/2020 01:06 AM

Average star voting: 3 ⭐ ( 74010 reviews)

Summary: Within a biofilm, the organisms are embedded in a glycocalyx. The glycocalyx is a self-produced matrix of extracellular polymeric substance (EPS) which consists of polysaccharides, lipids, proteins, and extracellular DNA.

Match with the search results: Consequently, these treatments are often ineffective against pathogenic biofilms (Costerton et al., 1987; ……. read more

Biofilm in dermatology - Journal of Skin and Sexually Transmitted Diseases

13. ESCMID∗ guideline for the diagnosis and treatment of biofilm infections 2014 – Clinical Microbiology and Infection

Author: jsstd.org

Date Submitted: 01/25/2021 07:40 AM

Average star voting: 5 ⭐ ( 93569 reviews)

Summary:

Match with the search results: Eventually, they become resistant to the treatment and in the end, antibiotics will no longer work to fight off the infection at all. Figure 1 – ……. read more

ESCMID∗ guideline for the diagnosis and treatment of biofilm infections 2014 - Clinical Microbiology and Infection

14. Novel Treatment Strategies for Biofilm-Based Infections | SpringerLink

Author: www.clinicalmicrobiologyandinfection.com

Date Submitted: 07/09/2021 12:22 AM

Average star voting: 5 ⭐ ( 77136 reviews)

Summary: Biofilm-growing cells show an enhanced antimicrobial tolerance with respect to the same cells growing in a free-floating way. This is due to physical or ch

Match with the search results: One novel approach to treat biofilms is the use of photo inactivation where light is used to either directly damage bacteria by exciting intracellular ……. read more

Novel Treatment Strategies for Biofilm-Based Infections | SpringerLink

15. Pathogenesis and treatment concepts of orthopaedic biofilm infections

Author: link.springer.com

Date Submitted: 04/16/2020 05:46 AM

Average star voting: 3 ⭐ ( 20077 reviews)

Summary: Abstract. Implant-associated infection is caused by surface-adhering bacteria persisting as biofilm. Periprosthetic joint infection is difficult to diagnose and

Match with the search results: Antibiotic after antibiotic for IBD. Corticosteroids for CRS. If a biofilm is at work, these standard “treatments” aren’t curing anything….. read more

Pathogenesis and treatment concepts of orthopaedic biofilm infections

16. Biofilms | Richmond Sinus & Allergy

Author: www.youtube.com

Date Submitted: 03/28/2021 02:54 AM

Average star voting: 3 ⭐ ( 36905 reviews)

Summary: Learn about the role biofilms play in chronic infections of the ears and sinuses

Match with the search results: Ultrasound debridement can treat biofilm-infected wounds, and has been reported to increase the effectiveness of antibiotics and promote wound healing [52], [53] ……. read more

Biofilms | Richmond Sinus & Allergy

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