Top 5 vulvar lichen sclerosus treatment in 2022

Below are the best information and knowledge on the subject vulvar lichen sclerosus treatment compiled and compiled by our own team alltopus:

1. Therapeutic comparison between treatments for Vulvar Lichen Sclerosus: study protocol of a randomized prospective and controlled trial – BMC Women’s Health

Author: www.mayoclinic.org

Date Submitted: 04/28/2019 11:44 PM

Average star voting: 5 ⭐ ( 71737 reviews)

Summary: Vulvar lichen sclerosus (VLS) is a lymphocyte-mediated disease of unknown etiology that can cause intense itching as well stenosis, hindering the evacuation and urination. It can also limit the sex life due to severe local pruritus, pain and dyspareunia (pain during sexual intercourse). The standard treatment for this disease is the use of topical corticosteroids to reduce the clinical symptoms and to try to increase disease-free intervals. Photodynamic therapy (PDT), a treatment that associates a light radiation with a photosensitizing agent and photobiomodulation (PBM) are therapies that can promote effective immunomodulatory responses at the application site by means of photophysical and photochemical phenomena from the molecular to the systemic level, which promote their use in chronic dermatoses. The aim is to compare the effects of PDT, PBM, and topical corticosteroid in VLS evaluating clinical, histological, immunohistochemical and spectroscopic responses. The study is prospective, randomized and controlled, in a population of 60 women with histological diagnoses of VLS. There will be 3 treatments groups: PDT, PBM and topical corticosteroid (control group), where will be allocated by randomization 20 patients in each one. The clinical course will be monitored by measuring local temperature, itching, atrophy, and the area of the lesion. Histologically, the slides will be classified and will have the ordering of collagen fibers quantified. Immunohistochemical analysis will be done using the markers IFN-γ, TGF-β, CD4, CD8, IL-1, p53 and Ki-67. Finally, the spectroscopic evaluation will be done by reflectance. Descriptive and inferential statistical analyses will be conducted to compare the groups and make associations between different responses. The study is an open-label for patients with active symptomatic disease with a period of 1 year follow-up to determine the rate of recurrence in each groups. The immunological effects of PDT and PBM are described by several authors in inflammatory skin diseases, stimulating the production and organization of the associated collagen. Thus, it is reasonable to determine the efficacy and safety of these new treatments in VLS, in comparison to the control group, analyzing the recurrence time, the impact on the optical properties of the skin, and the benefit to patients. ClinicalTrials.gov: NCT02416531 .

Match with the search results: are commonly prescribed for lichen sclerosus. Initially, you’ll generally have to use cortisone creams or ointments on the affected skin twice a day. After several weeks, your doctor will likely recommend that you only use these medications twice a week to prevent a recurrence….. read more

Therapeutic comparison between treatments for Vulvar Lichen Sclerosus: study protocol of a randomized prospective and controlled trial - BMC Women's Health

2. Use of Er:YAG laser in the treatment of vulvar lichen sclerosus

Author: www.mayoclinic.org

Date Submitted: 12/24/2020 07:14 AM

Average star voting: 4 ⭐ ( 51157 reviews)

Summary:

Match with the search results: Your doctor can suggest treatment with creams or ointments that help return a more normal appearance to your skin and decrease the tendency for ……. read more

Use of Er:YAG laser in the treatment of vulvar lichen sclerosus

3. Lichen sclerosus: Review of a vulvar dystrophy with malignant potential

Author: www.uptodate.com

Date Submitted: 03/13/2021 08:51 PM

Average star voting: 3 ⭐ ( 90337 reviews)

Summary: This acquired chronic dermatosis has a 6- to 10-fold predilection for women, so it is especially relevant to a gynecologist’s practice.

Match with the search results: Steroid ointments are recommended to reduce inflammation and itching. They are the treatment of choice for genital LS. Strong steroid ointments ……. read more

Lichen sclerosus: Review of a vulvar dystrophy with malignant potential

4. Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists | SpringerLink

Author: www.cedars-sinai.org

Date Submitted: 12/08/2021 10:31 AM

Average star voting: 3 ⭐ ( 93505 reviews)

Summary: Vulvar lichen sclerosus is an important skin disease that is common in women in their 50 s and beyond; however, it can also affect females of any

Match with the search results: How is lichen sclerosus treated? ; Steroid injections. These are more likely to be used if steroid ointment doesn’t work well. ; Tricyclic antidepressants at low ……. read more

Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists | SpringerLink

5. Surgical Treatment of Vulvar Lichen Sclerosus: A Review : Obstetrical & Gynecological Survey

Author: jamanetwork.com

Date Submitted: 09/01/2020 07:32 PM

Average star voting: 4 ⭐ ( 80471 reviews)

Summary:

Match with the search results: Topically applied testosterone is frequently considered effective in lichen sclerosus. A prospective, randomized, placebo-controlled study, however, showed a ……. read more

Surgical Treatment of Vulvar Lichen Sclerosus: A Review : Obstetrical & Gynecological Survey

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